CDK4/6 inhibition in locally advanced/metastatic chordoma (NCT PMO-1601)
نویسندگان
چکیده
منابع مشابه
W ? S 1601 Policy Research Working Paper 1601
The Domestic Benefits Tropical forests can potentially produce hydrological benefits of Tropical Forests and yield economically vafuable nontimber forest A Critical Review Emphasizing products. But the levels of these benefits are poorly Hydrological Functions understood, likely to be highly context-specific. and Kenneth M. Chomitz may often be smaller than Kanta Kumari popularly supposed. This...
متن کاملDmd065094 1601..1611
Presystemic interactions with gut microbiota might play important roles in the holistic action of herbal medicines in their traditional oral applications. However, research interests usually focus on biologic activities of the in vivo available herb-derived components and their exposure in circulation. In this study, we illustrated the importance of studying the presystemic interplay with gut m...
متن کاملCombination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.
BACKGROUND Chordomas are rare tumors of the axial skeleton for which surgical resection remains the most reliable means of cure. PI-103 is a inhibitor of PI3K/AKT and mTOR activation. This study aims to determine whether the PI3K/mTOR pathway was active in chordomas and whether their inhibition could lead to decreased proliferation and increased apoptosis. MATERIALS AND METHODS Thirteen human...
متن کاملCombined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma
BACKGROUND The majority of chordomas show activation of the platelet-derived growth factor receptor (PDGFR). Based on in vitro intertumoral variation in response to recombinant PDGF protein and PDGFR inhibition, and variable tumor response to imatinib, we hypothesized that chordomas resistant to PDGFR inhibition may possess downstream activation of the pathway. METHODS Molecular profiling was...
متن کاملChordoma
PURPOSES To review in the literature, all the epidemiological, clinical, radiological, histological and therapeutic data regarding chordomas as well as various notochordal entities: ecchordosis physaliphora, intradural and intraparenchymatous chordomas, benign notochordal cell tumors, parachordomas and extra-axial chordomas. To identify different types of chordomas, including familial forms, as...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2017
ISSN: 0923-7534
DOI: 10.1093/annonc/mdx387.051